AB1018 BASELINE CHARACTERISTICS OF AN EARLY SPONDYLOARTHRITIS COHORT IN HONG KONG

Background Axial Spondyloarthritis (axSpA) is characterized by inflammation of the sacroiliac joint and spine. It a heterogeneous disease with variable musculoskeletal extra-articular manifestations. The Be l G ian I nflammatory A rthritis spo N dylitis cohor T (Be-Giant) cohort that recruited newly diagnosed SpA patients in Belgium prospectively followed up patients. Objectives Given difference genetic susceptibility environmental exposure, we aimed to compare nature, clinical presentation, prognosis between Chinese Caucasian axSpA Methods SPARK ( SP ondylo AR thritis Hong K ong) resembled Be-Giant cohort. Newly diagnosed, biologic naïve who fulfilled ASAS classification criteria were recruited. All underwent standardized clinical, laboratory radiographic assessments as per protocol. Results total 53 (Table 1). mean age at diagnosis (32 years old) symptom duration (2 years) comparable both cohorts. There was slight male predominance (59%) compared (50%). More HLAB27 positive (SPARK 96% vs 71%). In cohorts, less than one-fifth had sacroiliitis according modified New York 17% 18%). Patients similar activity clinically ASDAS-CRP 2.4 (SD 0.9) 2.6 1.0)) radiographically MRI SIJ definition 53% 87%). (37%) experienced uveitis (12%). Around 9% 5% suffered from psoriasis inflammatory bowel diseases (IBD) respectively while none did. Enthesitis (28%) dactylitis (3.8%) more common Belgians. Whereas peripheral arthritis Belgians Conclusion display burden regarding axial disease, yet appear be different extent on extra-musculoskeletal Table 1. Baseline demographic characteristics (n=257) (n=53) Male, no % 128 (49.8%) 31 (58.5%) Age diagnosis, 32 (8.3) 32(7.9) Symptoms duration, months 27 (10-83) 24 (13-54) Current smoker, 52 (20.5%) 10 (18.9%) HLAB27, 181 (70.7%) 51 (96.2%) Peripheral manifestation Enthesitis, (%) (9.3%) 15 (28.3%) Arthritis, no. 38 (14.8%) 6 (11.3%) Dactylitis, 5 (1.9%) 2 Extra-musculoskeletal (now/ever) Acute anterior (12.1%) 20 (37.7%) Psoriasis 23 (8.9%) 0 IBD 12 (4.7%) ASDASCRP, mean+-SD (1.0) (0.93) BASDAI, 4.3 (2.0) 3.7 (2.2) REFERENCES: NIL. Acknowledgements: Disclosure Interests Jacqueline So: None declared, Ann-Sophie De Craemer: Manouk de Hooge Consultant of: consultancy fees UCB, Sze-Lok Lau: Filip van den Bosch: Dirk Elewaut: Lai-Shan Tam: declared.